{"id":179,"date":"2021-02-19T20:30:35","date_gmt":"2021-02-19T19:30:35","guid":{"rendered":"https:\/\/translational-epigenetics.fr\/?page_id=179"},"modified":"2024-11-26T10:44:34","modified_gmt":"2024-11-26T09:44:34","slug":"homev2","status":"publish","type":"page","link":"https:\/\/translational-epigenetics.fr\/","title":{"rendered":"HomeV2"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"179\" class=\"elementor elementor-179\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-15c5387 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"15c5387\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f7a1e7b\" data-id=\"f7a1e7b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8834865 elementor-widget elementor-widget-heading\" data-id=\"8834865\" data-element_type=\"widget\" id=\"home\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bienvenue !!<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e5bbae7 elementor-arrows-position-inside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel\" data-id=\"e5bbae7\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;1&quot;,&quot;navigation&quot;:&quot;both&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;effect&quot;:&quot;slide&quot;,&quot;speed&quot;:500}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-carousel-wrapper swiper\" dir=\"ltr\">\n\t\t\t<div class=\"elementor-image-carousel swiper-wrapper\" aria-live=\"off\">\n\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"1 of 3\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Home2_PanoGrenoble-2.png\" alt=\"Home2_PanoGrenoble\" \/><\/figure><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"2 of 3\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Home4_IAB.png\" alt=\"Home4_IAB\" \/><\/figure><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"3 of 3\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/home3_Team-1.png\" alt=\"home3_Team\" \/><\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-left\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-right\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-61e078d elementor-widget elementor-widget-text-editor\" data-id=\"61e078d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>We are a r<strong>esearch team located in Grenoble<\/strong>, French Alpes, in the Department <em><a href=\"https:\/\/iab.univ-grenoble-alpes.fr\/research\/department-signaling-through-chromatin?language=en\" target=\"_blank\" rel=\"noopener\">Signaling Through Chromatin<\/a><\/em> of the <em><a href=\"https:\/\/iab.univ-grenoble-alpes.fr\/?language=en\" target=\"_blank\" rel=\"noopener\">Institute of Advanced Biosciences<\/a><\/em>.<\/p><p>We aim to explore <strong>chromatin signaling<\/strong>, how its deregulation can lead to <strong>pathological states<\/strong> and could be targeted to <strong>treat human diseases<\/strong>.<\/p><p>We are always looking for talented members. <a href=\"#contact\"><em>Contact us!<\/em><\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1a081ab elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1a081ab\" data-element_type=\"section\" data-settings=\"{&quot;shape_divider_top&quot;:&quot;mountains&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" opacity=\"0.33\" d=\"M473,67.3c-203.9,88.3-263.1-34-320.3,0C66,119.1,0,59.7,0,59.7V0h1000v59.7 c0,0-62.1,26.1-94.9,29.3c-32.8,3.3-62.8-12.3-75.8-22.1C806,49.6,745.3,8.7,694.9,4.7S492.4,59,473,67.3z\"\/>\n\t<path class=\"elementor-shape-fill\" opacity=\"0.66\" d=\"M734,67.3c-45.5,0-77.2-23.2-129.1-39.1c-28.6-8.7-150.3-10.1-254,39.1 s-91.7-34.4-149.2,0C115.7,118.3,0,39.8,0,39.8V0h1000v36.5c0,0-28.2-18.5-92.1-18.5C810.2,18.1,775.7,67.3,734,67.3z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M766.1,28.9c-200-57.5-266,65.5-395.1,19.5C242,1.8,242,5.4,184.8,20.6C128,35.8,132.3,44.9,89.9,52.5C28.6,63.7,0,0,0,0 h1000c0,0-9.9,40.9-83.6,48.1S829.6,47,766.1,28.9z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-316be16\" data-id=\"316be16\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9d51ca6 elementor-widget elementor-widget-heading\" data-id=\"9d51ca6\" data-element_type=\"widget\" id=\"news\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">News &amp; more<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e25c97f elementor-widget elementor-widget-text-editor\" data-id=\"e25c97f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>Last news<\/strong> (all news are <a href=\"https:\/\/translational-epigenetics.fr\/?post_type=post\" target=\"_blank\" rel=\"noopener\" data-wplink-edit=\"true\">here<\/a>)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3216e4c elementor-grid-eael-col-4 elementor-grid-tablet-eael-col-2 elementor-grid-mobile-eael-col-1 elementor-widget elementor-widget-eael-post-grid\" data-id=\"3216e4c\" data-element_type=\"widget\" data-settings=\"{&quot;eael_post_grid_columns&quot;:&quot;eael-col-4&quot;,&quot;eael_post_grid_columns_tablet&quot;:&quot;eael-col-2&quot;,&quot;eael_post_grid_columns_mobile&quot;:&quot;eael-col-1&quot;}\" data-widget_type=\"eael-post-grid.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div id=\"eael-post-grid-3216e4c\" class=\"eael-post-grid-container\">\n            <div class=\"eael-post-grid eael-post-appender eael-post-appender-3216e4c eael-post-grid-style-one\" data-layout-mode=\"masonry\"><article class=\"eael-grid-post eael-post-grid-column\" data-id=\"776\">\n        <div class=\"eael-grid-post-holder\">\n            <div class=\"eael-grid-post-holder-inner\"><div class=\"eael-entry-wrapper\"><header class=\"eael-entry-header\"><h2 class=\"eael-entry-title\"><a\n                        class=\"eael-grid-post-link\"\n                        href=\"https:\/\/translational-epigenetics.fr\/index.php\/2024\/11\/26\/elementor-776\/\"\n                        title=\"Summer school 2025 on Epigenetics and Metabolism\">Summer school 2025 on Epigenetics and Metabolism<\/a><\/h2><\/header><div class=\"eael-entry-content\">\n                        <div class=\"eael-grid-post-excerpt\"><p>We are working veyr hard to create a summer school...<\/p><a href=\"https:\/\/translational-epigenetics.fr\/index.php\/2024\/11\/26\/elementor-776\/\" class=\"eael-post-elements-readmore-btn\">Read More<\/a><\/div>\n                    <\/div><div class=\"eael-entry-footer\"><div class=\"eael-author-avatar\"><a href=\"https:\/\/translational-epigenetics.fr\/index.php\/author\/admin4354\/\"><img alt=' ' src='https:\/\/secure.gravatar.com\/avatar\/c8f56cb18311a9830b4ef1987d7a0d8de4943a8ad1ebb215e77989004a710ec8?s=96&#038;d=mm&#038;r=g' srcset='https:\/\/secure.gravatar.com\/avatar\/c8f56cb18311a9830b4ef1987d7a0d8de4943a8ad1ebb215e77989004a710ec8?s=192&#038;d=mm&#038;r=g 2x' class='avatar avatar-96 photo' height='96' width='96' \/><\/a><\/div><div class=\"eael-entry-meta\"><span class=\"eael-posted-by\"><a href=\"https:\/\/translational-epigenetics.fr\/index.php\/author\/admin4354\/\" title=\"Posts by  \" rel=\"author\"> <\/a><\/span><span class=\"eael-posted-on\"><time datetime=\"November 26, 2024\">November 26, 2024<\/time><\/span><\/div><\/div><\/div><\/div>\n        <\/div>\n    <\/article><\/div>\n            <div class=\"clearfix\"><\/div>\n        <\/div>            <div class=\"eael-load-more-button-wrap eael-force-hide\">\n                <button class=\"eael-load-more-button\" id=\"eael-load-more-btn-3216e4c\" data-widget-id=\"3216e4c\" data-widget=\"3216e4c\" data-page-id=\"179\" data-template=\"{&quot;dir&quot;:&quot;lite&quot;,&quot;file_name&quot;:&quot;default.php&quot;,&quot;name&quot;:&quot;Post-Grid&quot;}\" data-class=\"Essential_Addons_Elementor\\Elements\\Post_Grid\" data-layout=\"masonry\" data-page=\"1\" data-args=\"orderby=date&amp;order=desc&amp;ignore_sticky_posts=1&amp;post_status=publish&amp;posts_per_page=1&amp;offset=0&amp;post_type=post\" data-max-page=\"11\">\n                    <span class=\"eael-btn-loader button__loader\"><\/span>\n                    <span class=\"eael_load_more_text\">Load More<\/span>\n                <\/button>\n            <\/div>\n            \t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-59f24d5 elementor-widget elementor-widget-text-editor\" data-id=\"59f24d5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>We&#8217;re now on Bluesky: <a href=\"https:\/\/bsky.app\/profile\/jeromegovin.bsky.social\" target=\"_blank\" rel=\"noopener\">here<\/a> !<br \/><\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f13d2a elementor-widget elementor-widget-eael-twitter-feed\" data-id=\"4f13d2a\" data-element_type=\"widget\" data-settings=\"{&quot;pagination&quot;:&quot;false&quot;}\" data-widget_type=\"eael-twitter-feed.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t \n        <div>\n            <div class=\"eael-twitter-feed eael-twitter-feed-4f13d2a eael-twitter-feed-masonry eael-twitter-feed-col-3 clearfix\" data-gutter=\"10\" data-posts-per-page=\"\" data-total-posts=\"10\" data-nomore-item-text=\"\" data-next-page=\"2\" >\n                            <\/div>\n            <div class=\"clearfix\">\n                            <\/div>\n        <\/div>\n\n        <style>\n            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.eael-twitter-feed-4f13d2a.eael-twitter-feed-masonry.eael-twitter-feed-col-3 .eael-twitter-feed-item,\n                .eael-twitter-feed-4f13d2a.eael-twitter-feed-masonry.eael-twitter-feed-col-4 .eael-twitter-feed-item {\n                    width: calc(50% - 5px);\n                }\n            }\n        <\/style>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-93b6de1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"93b6de1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-92b1401\" data-id=\"92b1401\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eb5f586 elementor-widget elementor-widget-heading\" data-id=\"eb5f586\" data-element_type=\"widget\" id=\"team\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">About the team<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c3e1b7 elementor-widget elementor-widget-eael-adv-accordion\" data-id=\"3c3e1b7\" data-element_type=\"widget\" data-widget_type=\"eael-adv-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t        <div class=\"eael-adv-accordion\" id=\"eael-adv-accordion-3c3e1b7\" data-scroll-on-click=\"no\" data-scroll-speed=\"300\" data-accordion-id=\"3c3e1b7\" data-accordion-type=\"accordion\" data-toogle-speed=\"300\">\n    <div class=\"eael-accordion-list\">\n                <div id=\"why-translational-epigenetics\" class=\"elementor-tab-title eael-accordion-header active-default\" tabindex=\"0\" data-tab=\"1\" aria-controls=\"elementor-tab-content-6311\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-clinic-medical\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Why translational epigenetics?<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-6311\" class=\"eael-accordion-content clearfix active-default\" data-tab=\"1\" aria-labelledby=\"why-translational-epigenetics\"><p>Our team explores <strong>chromatin signaling pathways<\/strong> and how they are deregulated in <strong>human diseases<\/strong>.<\/p><p>We are investigating fundamental aspects of chromatin biology in model organisms and nuclear signaling. Indeed, we leverage a wide range of expertise in epigenomics, molecular and cell biology, biochemistry, structural biology, and bioinformatics.<\/p><p>Our team benefits from the active involvement of several clinicians who participate in national and international medical networks to develop our translational research programs. This allows us to further structure translational research in epigenetics in collaboration with Grenoble Alpes University Hospital (CHUGA).<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"team-environment\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"2\" aria-controls=\"elementor-tab-content-6312\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fab fa-envira\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Team environment<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-6312\" class=\"eael-accordion-content clearfix\" data-tab=\"2\" aria-labelledby=\"team-environment\"><p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-204 alignleft\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Grenoble-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Grenoble-300x225.jpg 300w, https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Grenoble.jpg 400w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>Grenoble is an international center of excellence for R&amp;D, recognized by Forbes as the 5th most innovative city in the world in 2013.<\/p><p>With 80,000 jobs in R&amp;D (7.1% of the population, ranking n\u00b01 in France), the science community of Grenoble offers the attractions of an exceptionally dense research plateau, together with a unique supportive atmosphere for investment and business development, within an outstanding location at the foot of the French Alps.<\/p><p>Grenoble hosts top class research organizations such as EMBL, CNRS, Inserm, INRIA, INRAE, CEA and IRSTEA. It benefits from an international high-tech cluster on digital and nano technologies, as well as R&amp;D centers of multinational industrial R&amp;D leaders (STMicroelectronics, Schneider Electric, etc).<\/p><p>Finally, Grenoble benefits from an outstanding quality of life, with a broad diversity of culture and sportive activities. More information on the <a href=\"https:\/\/www.giant-grenoble.org\/en\/getting-there-and-around\/\" target=\"_blank\" rel=\"noopener\">Giant Genoble website<\/a>.<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"team-policy\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"3\" aria-controls=\"elementor-tab-content-6313\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-clipboard\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Team policy<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-6313\" class=\"eael-accordion-content clearfix\" data-tab=\"3\" aria-labelledby=\"team-policy\"><div id=\"elementor-tab-content-3664\" class=\"elementor-tab-content elementor-clearfix elementor-active\" tabindex=\"0\" role=\"tabpanel\" data-tab=\"4\" aria-labelledby=\"elementor-tab-title-3664\"><p><strong>Our objective<\/strong><\/p><p>Improve clinical care with translational research in epigenetics<\/p><p>\u00a0<\/p><p><strong>Our vision<br \/><\/strong><\/p><ul><li>Combine various model organisms to reveal new epigenetic mechanisms, with potential clinical applications.<\/li><li>Discuss and collaborate.<\/li><li>Contribute to open science. Share protocols, reagents and data.<\/li><li>Promote scientific, moral and ethical consciousness with a safe, respectfull and rewarding professional environment.<\/li><\/ul><p>\u00a0<\/p><p><strong>Our responsibilities <\/strong><\/p><ul><li>Actively welcome new members with scientific and experimental guidance.<\/li><li>Provide for your salary\/stipend, research materials, computational resources and physical workspace.<\/li><li>Create and support your attendance at scientific courses, conferences, tutorials, and workshops. Lab members generally attend at least one conference\/year.<\/li><li>Provide career advice and mentoring. Support any career of your choice and help you secure your future job.<\/li><li>Provide an environment where ethical behavior is expected and where interpersonal conflicts and unethical behavior are handled in a professional manner.<\/li><li>Promote the values of Gender Equity, Diversity and Inclusion within the team&#8217;s environment.<\/li><li>Keep optimizing the team\u2019s organization to maximize time dedicated to science while minimizing bureaucracy.<\/li><li>Provide fair authorship on publications, following the guidelines of The International Committee of Medical Journal Editors (<a href=\"http:\/\/www.icmje.org\/recommendations\/browse\/roles-and-responsibilities\/defining-the-role-of-authors-and-contributors.html\" target=\"_blank\" rel=\"noopener\">link<\/a>).<\/li><\/ul><p>\u00a0<\/p><p><strong>Your commitments<\/strong><\/p><ul><li>Always have a professional behavior in line with the team values: respectful, responsible, inclusive and open-minded.<\/li><li>Properly document your scientific work with all experimental conditions. We expect to be able to revisit any experiment without your assistance when you will be gone.<\/li><li>Enthusiastically participate in the team life (lab meetings, journal clubs) and fulfill your lab jobs.<\/li><li>Use the team tools for scheduled meetings and reporting vacation\/sick time.<\/li><li>Inform leadership if you experience any problem (working relationship, getting the resources, advice, or training you need.<\/li><li>Give credit when due. Obey intellectual property laws. Respect the confidentiality of internal and collaborators\u2019 projects<\/li><li>Contribute to the lab\u2019s culture of exceptional thoughtfulness and intellectual rigor so we can all continue to enjoy a healthy research environment.<\/li><\/ul><\/div><\/div>\n                <\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d110e53 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d110e53\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c5e624c\" data-id=\"c5e624c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5fcce49 elementor-widget elementor-widget-heading\" data-id=\"5fcce49\" data-element_type=\"widget\" id=\"research\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Our research program<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2fbbc46 elementor-widget elementor-widget-heading\" data-id=\"2fbbc46\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Overview<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8bc91 elementor-widget elementor-widget-text-editor\" data-id=\"ea8bc91\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Our team explores <strong>chromatin signaling pathways<\/strong> and how they are deregulated in <strong>human diseases<\/strong>. Specifically, we study how chromatin factors control genome organization, gene expression, and cell identity. These mechanisms are largely conserved throughout evolution, from yeast to humans.<br \/><br \/>We investigate <strong>fundamental aspects of chromatin biology<\/strong> in model organisms and nuclear signaling in two distinct pathological contexts: infectious diseases and hematological cancers. For example, our work has led to demonstrating that a novel epigenetic reader is a potential drug target to treat pathogenic fungal infections. We also study abnormal gene expression in aggressive B-cell lymphomas to identify novel cancer drivers. This approach has revealed new lymphomagenesis pathways, including potential novel predictive biomarkers and targets for epigenetic-based therapies.<br \/><br \/>We leverage a<strong> wide range of expertise<\/strong> in epigenomics, molecular and cell biology, biochemistry, structural biology, and bioinformatics. We also benefit from the <strong>active involvement of several clinicians<\/strong> who participate in national and international medical networks to develop our translational research programs.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a1a285 elementor-widget elementor-widget-heading\" data-id=\"5a1a285\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">More on our research program<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4a09fe elementor-widget elementor-widget-eael-adv-accordion\" data-id=\"a4a09fe\" data-element_type=\"widget\" data-widget_type=\"eael-adv-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t        <div class=\"eael-adv-accordion\" id=\"eael-adv-accordion-a4a09fe\" data-scroll-on-click=\"no\" data-scroll-speed=\"300\" data-accordion-id=\"a4a09fe\" data-accordion-type=\"accordion\" data-toogle-speed=\"300\">\n    <div class=\"eael-accordion-list\">\n                <div id=\"cutting-edge-research-in-epigenetics\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"1\" aria-controls=\"elementor-tab-content-1721\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-random\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Cutting-edge research in epigenetics<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-1721\" class=\"eael-accordion-content clearfix\" data-tab=\"1\" aria-labelledby=\"cutting-edge-research-in-epigenetics\"><p>We are pursuing our fundamental exploration of epigenetic mechanisms in model organisms, notably sexual differentiation in the yeast <em>S. cerevisiae<\/em>. This work is be also carried out in models of aggressive lymphomas, for which treatment resistance currently remains a real clinical challenge. These two application models are perfectly suited to study the intricate link between epigenetic-mediated control of gene expression and the metabolic state of cells. Our current and future projects will therefore be focused on addressing the cross-talk between metabolism and epigenetics.<\/p><p>In addition, our projects will integrate single cell technologies to better capture epigenetic heterogeneity, notably to detect the emergence of drug-resistant cell populations and their contribution to disease progression. These approaches are being implemented in close connection with clinicians (infectiology \/ onco-hematology).<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"pursuing-our-translational-approach\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"2\" aria-controls=\"elementor-tab-content-1722\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-ambulance\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Pursuing our translational approach<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-1722\" class=\"eael-accordion-content clearfix\" data-tab=\"2\" aria-labelledby=\"pursuing-our-translational-approach\"><p>We have an optimal configuration to carry out truly operational translational research in epigenetics with both experts in biology, epigenetic signaling and medical care. The team comprises 7 physicians, including S. Carras (PHU), PI in the team, but also deputy director of the CHUGA Clinical Research and Innovation Direction (DRCI), and of the Biological Resources Center (CRB).<\/p><p>This active involvement of hospital staff, as well as the perfect alignment of our research objectives with the CHUGA\/HCERES axis \u201cEpigenetic, cancer and infertility\u201d put us in a particularly effective position to conduct genuine translational research. We are also increasingly committed to national actions, through for instance, our involvement in the scientific board of the Lymphoma Study Association (LYSA).<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"structuring-a-strong-community-centered-on-epigenetics\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"3\" aria-controls=\"elementor-tab-content-1723\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-people-carry\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Structuring a strong community centered on epigenetics<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-1723\" class=\"eael-accordion-content clearfix\" data-tab=\"3\" aria-labelledby=\"structuring-a-strong-community-centered-on-epigenetics\"><p>Our team is also promoting the development of the local epigenetics community, especially within the Health Campus.<\/p><p>With J\u00e9r\u00f4me Govin leading the epigenetics department, we are actively working \u00a0with our colleagues to further develop this community, boost its research potential and increase its local, national and international visibility through structuring actions, teaching and scientific animations (Meetings \u201cInterface Clinics &amp; Epigenetics\u201d, <a href=\"https:\/\/epigenetics.fr\/\" target=\"_blank\" rel=\"noopener\">Grenoble Epigenetics Club<\/a>, Memorandum of Understanding IAB-EMBL).<\/p><\/div>\n                <\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae6fb50 elementor-widget elementor-widget-heading\" data-id=\"ae6fb50\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">A selection of our on-going projects<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94d52bd elementor-widget elementor-widget-eael-adv-accordion\" data-id=\"94d52bd\" data-element_type=\"widget\" data-widget_type=\"eael-adv-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t        <div class=\"eael-adv-accordion\" id=\"eael-adv-accordion-94d52bd\" data-scroll-on-click=\"no\" data-scroll-speed=\"300\" data-accordion-id=\"94d52bd\" data-accordion-type=\"accordion\" data-toogle-speed=\"300\">\n    <div class=\"eael-accordion-list\">\n                <div id=\"epigenetics-in-yeast-spores\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"1\" aria-controls=\"elementor-tab-content-1561\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-vial\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Epigenetics in yeast spores<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-1561\" class=\"eael-accordion-content clearfix\" data-tab=\"1\" aria-labelledby=\"epigenetics-in-yeast-spores\"><p>This research program focuses on epigenetics and chromatin in yeast spores. Yeast sporulation is a widely established model for studying meiosis. However, post-meiotic events and the final differentiation of spores remain largely unexplored. In particular, spores display a very distinct organization of chromatin, which is highly compacted, but ready to reactivate rapidly when given nutrients. We are exploring how chromatin compaction conditions the gene expression program.<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"epigenetics-in-aggressive-b-cell-lymphomas\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"2\" aria-controls=\"elementor-tab-content-1562\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-briefcase-medical\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Epigenetics in aggressive B-cell lymphomas<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-1562\" class=\"eael-accordion-content clearfix\" data-tab=\"2\" aria-labelledby=\"epigenetics-in-aggressive-b-cell-lymphomas\"><p>We are particularly interested in the mechanisms by which tumor cells escape the epigenetic controls that govern their somatic identity, enabling them to acquire aberrant identities. In collaboration with the EpiMed platform (IAB), we have adapted a bioinformatics pipeline, which was applied to transcriptomic data from large patient cohorts to identify \u201coff-context\u201d gene expression in lymphoma. This innovative approach has unraveled several aberrant gene reactivations associated with patient prognosis that are being functionally investigated with the objective of identifying novel druggable cell vulnerabilities.<\/p><p>Diffuse large-cell lymphoma (DLBCL) is an aggressive and frequent hematological malignancy. DLBCLs are driven by major epigenetic deregulations, as they harbor many mutations in chromatin factors. DLBCL therefore represents an attractive system to study the link between epigenetic deregulation and therapeutic resistance. We are currently investigating how these alterations shape the epigenetic landscapes and how their heterogeneity conditions the emergence of persistent cell populations using cutting edge single-cell epigenomics. In this objective, we are exploiting various lymphoma models and patient cohorts to reveal novel epigenomic mechanisms of lymphoma progression and resistance.<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"therapeutic-targeting-of-chromatin-regulators\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"3\" aria-controls=\"elementor-tab-content-1563\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon far fa-arrow-alt-circle-right\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Therapeutic targeting of chromatin regulators<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-1563\" class=\"eael-accordion-content clearfix\" data-tab=\"3\" aria-labelledby=\"therapeutic-targeting-of-chromatin-regulators\"><p>A first project is developing <strong>new molecules capable of acting on infections by pathogenic fungi<\/strong>. These infections kill around 1.6 million people every year, as many as tuberculosis or malaria. The alarming increase in drug-resistant strains, combined with the toxicity, high cost and limited repertoire of available drugs, has created an urgent need for new therapeutic agents.<\/p><p>We collaborated with Carlo Petosa (<a href=\"https:\/\/www.ibs.fr\/en\/research\/assembly-dynamics-and-reactivity\/epigenetics-and-molecular-pathways-group-c-petosa\/petosa-team\/?lang=en\" target=\"_blank\" rel=\"noopener\">Structural Biology, IBS<\/a>) and Charles McKenna (<a href=\"https:\/\/dornsife.usc.edu\/mckusc\/\" target=\"_blank\" rel=\"noopener\">Medicinal Chemistry, USC, Los Angeles, USA<\/a>), creating the perfect opportunity to transfer our expertise on the Bdf1 protein to biomedical applications. By screening chemical libraries, we have identified small-molecule compounds that inhibit this protein in pathogenic yeasts of the <em>Candida<\/em> genus. These results could ultimately lead to the development of new classes of antifungal drugs.<\/p><p>We are also interested in how <strong>epigenetic inhibitors can be used to treat high-grade B lymphomas<\/strong>. We are particularly interested in bromodomain inhibitors, to better characterize their molecular targets and rationalize their clinical use as single agents or in combination therapies.<\/p><p>\u00a0<\/p><p>Finally, we are studying also the impact of a <strong>new generation of bromodomain inhibitors on the inflammatory response<\/strong>. We are evaluating the anti-inflammatory effect of a new generation of BET inhibitors, derived from an innovative synthesis route based on green chemistry (collaboration Yung-Sing Wong, DPM\/UGA) in cellular and preclinical models of inflammation (<em>in ovo<\/em> and in a rat model of inflammation-induced hepatocellular carcinoma, (collaboration T. Decaens \/ Z. Macek-Jilkova, IAB\/CHUGA and Inovotion).<\/p><\/div>\n                <\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-58efeab elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"58efeab\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2d498a0\" data-id=\"2d498a0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a25d62e elementor-widget elementor-widget-heading\" data-id=\"a25d62e\" data-element_type=\"widget\" id=\"people\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">People<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9f93413 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9f93413\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-fbfc0a7\" data-id=\"fbfc0a7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b0e3028 elementor-widget elementor-widget-eael-adv-accordion\" data-id=\"b0e3028\" data-element_type=\"widget\" data-widget_type=\"eael-adv-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t        <div class=\"eael-adv-accordion\" id=\"eael-adv-accordion-b0e3028\" data-scroll-on-click=\"no\" data-scroll-speed=\"300\" data-accordion-id=\"b0e3028\" data-accordion-type=\"accordion\" data-toogle-speed=\"300\">\n    <div class=\"eael-accordion-list\">\n                <div id=\"current-members\" class=\"elementor-tab-title eael-accordion-header active-default\" tabindex=\"0\" data-tab=\"1\" aria-controls=\"elementor-tab-content-1851\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-people-carry\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Current members<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-1851\" class=\"eael-accordion-content clearfix active-default\" data-tab=\"1\" aria-labelledby=\"current-members\"><p><strong>Permanent members<\/strong><\/p><ul><li><strong>J\u00e9r\u00f4me GOVIN (team leader) <a href=\"https:\/\/www.linkedin.com\/in\/jeromegovin\/?locale=en_US\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"alignnone wp-image-316 size-full\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Linkedin-e1614161737403.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/a> <a href=\"https:\/\/orcid.org\/0000-0001-5511-6965\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"alignnone size-full wp-image-253\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/index-e1613994717238.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/a><br \/><\/strong><\/li><li><strong>Anouk EMADALI (project leader, staff scientist) <a href=\"https:\/\/www.linkedin.com\/in\/anouk-emadali-390532a1\/?originalSubdomain=fr\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"alignnone wp-image-316 size-full\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Linkedin-e1614161737403.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/a> <\/strong><a href=\"https:\/\/orcid.org\/0000-0002-1976-2668\" target=\"_blank\" rel=\"noopener\"><strong><img decoding=\"async\" class=\"alignnone size-full wp-image-253\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/index-e1613994717238.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/strong><\/a><\/li><\/ul><ul><li>Marie ARLOTTO (lab manager)<\/li><li>Patricia BETTON (technician)<\/li><li>Thierry BONNEFOIX (staff scientist)<\/li><li>Thierry GAUTIER (staff scientist and University Lecturer)<\/li><li>Sieme HAMAIDIA (technician)<\/li><li>Emilie MONTAUT (statistics)<\/li><\/ul><p>\u00a0<\/p><p><strong>Post Docs and PhD students<\/strong><\/p><ul><li>Anna-Maria ALAZZI (PhD student)<\/li><li>Rapha\u00ebl DUPEYRON (PhD student)<\/li><li>Andrea GARCIA SANDOVAL (PhD student)<\/li><\/ul><p>\u00a0<\/p><p><strong>Clinicians<\/strong><\/p><ul><li>Lucile BUSSOT<\/li><li>Sylvain CARRAS<\/li><li>R\u00e9my GRESSIN<\/li><li>Marie-Christine JACOB<\/li><li>Christine LEFEBVRE<\/li><li>Anne THIEBAUD-BERTRAND<\/li><\/ul><p>\u00a0<\/p><p><strong>Rotation students (2023 &#8211; 2024)<\/strong><\/p><ul><li>To be updated soon!<\/li><\/ul><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"alumni\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"2\" aria-controls=\"elementor-tab-content-1852\"><span class=\"eael-advanced-accordion-icon-closed\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-history\"><\/i><\/span><span class=\"eael-advanced-accordion-icon-opened\"><i aria-hidden=\"true\" class=\"fa-accordion-icon fas fa-minus\"><\/i><\/span><span class=\"eael-accordion-tab-title\">Alumni<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-angle-right\"><\/i><\/div><div id=\"elementor-tab-content-1852\" class=\"eael-accordion-content clearfix\" data-tab=\"2\" aria-labelledby=\"alumni\"><p>We are proud that 100% of our former members have a fulfilling job.<\/p><p><strong>Post Docs &amp; PhD<\/strong><\/p><ul><li><strong>Encarna GARCIA-OLIVER<\/strong>, post doc. Now post doc in <a href=\"https:\/\/www.igmm.cnrs.fr\/en\/\" target=\"_blank\" rel=\"noopener\">IGMM<\/a>.<\/li><li><strong>Flore MIETTON<\/strong>, post doc. Now Chief Research Officer at the <a href=\"https:\/\/www.chu-grenoble.fr\/content\/le-diagnostic-pre-implantatoire-dpi\" target=\"_blank\" rel=\"noopener\">Fertility Department<\/a> of the Hospital of Grenoble. <a href=\"https:\/\/www.linkedin.com\/in\/flore-mietton-192a0b49\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-316\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Linkedin-e1614161737403.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/a><\/li><li><strong>Morgane CHAMPLEBOUX<\/strong>, PhD student. Now Research Scientist in Synthetic Biology in <a href=\"https:\/\/www.michelin.com\/\" target=\"_blank\" rel=\"noopener\">Michelin<\/a>. <a href=\"https:\/\/www.linkedin.com\/in\/morgane-champleboux-9ab69878\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-316\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Linkedin-e1614161737403.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/a><\/li><li><strong>Sara EL KENNANI<\/strong>, PhD student. Now Project leader in the <a href=\"https:\/\/www.linksium.fr\/en\/projects\/vaccyvet\" target=\"_blank\" rel=\"noopener\">AIOVA<\/a> start up (<a href=\"https:\/\/www.pavallab.com\/\" target=\"_blank\" rel=\"noopener\">Paval Lab<\/a>). <a href=\"https:\/\/www.linkedin.com\/in\/sara-el-kennani\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-316\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Linkedin-e1614161737403.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/a><\/li><li><strong>Kaiyao WEI<\/strong>, PhD student. Staff scientist in Pharmaceutical Industry in China. <a href=\"https:\/\/www.linkedin.com\/in\/kaiyao-wei-145313b3\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-316\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Linkedin-e1614161737403.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/a><\/li><li><strong>Loris DELRIEU<\/strong> (PhD student).<\/li><li><strong>Camille SAYOU<\/strong> (Post Doc). Now staff scientist at CEA.<\/li><li>\u00a0<\/li><\/ul><p><strong>Staff<\/strong><\/p><ul><li><strong>Jonathan PEROT<\/strong>, lab manager. Now research engineer with permanent position at <a href=\"https:\/\/promise-proteomics.com\/\" target=\"_blank\" rel=\"noopener\">Promise Proteomics<\/a>. <a href=\"https:\/\/www.linkedin.com\/in\/jonathan-perot-3a888646\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-316\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Linkedin-e1614161737403.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/a><\/li><li><strong>Julie MARAIS<\/strong>, technician. Now technician with permanent position at <a href=\"https:\/\/bgene-genetics.com\/en\/\" target=\"_blank\" rel=\"noopener\">BGene<\/a>.<\/li><li><strong>Ninon ZALA<\/strong>, technician. Now technician with permanent position in the <a href=\"https:\/\/www.ibs.fr\/research\/research-groups\/dynamics-and-kinetics-of-molecular-processes-group-m-weik\/\" target=\"_blank\" rel=\"noopener\">Institute of Structural Biology<\/a>. <a href=\"https:\/\/www.linkedin.com\/in\/ninon-zala-557093110\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-316\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/Linkedin-e1614161737403.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/a><\/li><li><strong>Morgane LAPEYRE<\/strong>, technician. Now technician in <a href=\"https:\/\/www.lpcv.fr\/en\/Pages\/Lipid\/Presentation.aspx\" target=\"_blank\" rel=\"noopener\">Cell &amp; Plant Physiology lab<\/a>.<\/li><li><strong>Jordan LYONNET<\/strong> (technician)<\/li><\/ul><p><strong>Former rotation students<br \/><\/strong><\/p><ul><li><strong>2023<\/strong>. Alexia TORROJA (Master, Clinician), Oriane VIRAVAUX (Master).<\/li><li><strong>2022<\/strong>. Oriane VIRAVAUX, (Master student), Camille TESTE (Master student), Fabien CLAVES (Master student, Clinician), Anna Maria ALAZZI (Master student).<\/li><\/ul><ul><li><strong>2021<\/strong>. L\u00e9a CERATO (Master student), Mathilde FORGET (Junior High School), Diane PLISSONIER (Bachelor student), Andrea CECILIA GARCIA SANDOVAL (Master student), Victoria RICCO (MD student), Juliette ROSSET (Junior High School), Camille TESTE (Master student).<\/li><\/ul><\/div>\n                <\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3bdbb08\" data-id=\"3bdbb08\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6a802c9 elementor-widget elementor-widget-image\" data-id=\"6a802c9\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"228\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/home3_Team-1-1024x292.png\" class=\"attachment-large size-large wp-image-270\" alt=\"\" srcset=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/home3_Team-1-1024x292.png 1024w, https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/home3_Team-1-300x86.png 300w, https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/home3_Team-1-768x219.png 768w, https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/home3_Team-1.png 1536w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cb986a1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cb986a1\" data-element_type=\"section\" id=\"publications\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d7207d3\" data-id=\"d7207d3\" data-element_type=\"column\" id=\"publications\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3e5e59e elementor-widget elementor-widget-heading\" data-id=\"3e5e59e\" data-element_type=\"widget\" id=\"publications\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Publications<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ccf702b elementor-widget elementor-widget-text-editor\" data-id=\"ccf702b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The full list of publications can be found <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28Govin%2C+Jerome+%5BAuthor%5D%29+OR+%28Emadali%2C+Anouk%5BAuthor%5D%29+OR+%28Carras+Sylvain%5BAuthor%5D%29+OR+%28Gressin%2C+Remy%5BAuthor%5D%29+OR+%28%28Lefebvre%2C+Christine%5BAuthor%5D%29+AND+%28Grenoble%5BAffiliation%5D%29%29+OR+%28Jacob%2C+Marie+Christine%5BAuthor%5D%29+OR+%28Thiebaut-Bertrand%2C+Anne%5BAuthor%5D%29+OR+%28gautier+thierry%5BAuthor%5D%29+OR+%28bonnefoix+thierry%5BAuthor%5D%29&amp;sort=date\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7470169 elementor-widget elementor-widget-text-editor\" data-id=\"7470169\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>Selection of our major papers<\/strong><\/p><ul><li>Wei K, et al. Targeting fungal BET bromodomains as a pan-Candida antifungal strategy. <em>bioRxiv.<\/em><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.02.03.527073v1\" target=\"_blank\" rel=\"noopener\">DOI<\/a><\/li><li>Carras S, et al. Long-term analysis of the RiBVD phase II trial reveals the unfavorable impact of TP53 mutations and hypoalbuminemia in older adults with mantle cell lymphoma. <em>Haematologica<\/em>. 2023 Nov 30.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38031755\/\" target=\"_blank\" rel=\"noopener\">PUBMED<\/a>. <a href=\"https:\/\/doi.org\/10.3324\/haematol.2023.283724\" target=\"_blank\" rel=\"noopener\">DOI<\/a>.<\/li><li>Bouroumeau A, et al (2021) Extranucleolar CYCLON Staining Pattern Is Strongly Associated to Relapse\/Refractory Disease in R-CHOP\u2013treated DLBCL. <em>HemaSphere<\/em>. <span id=\"ej-journal-date-volume-issue-pg\">5(7):e598. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34131636\/\" target=\"_blank\" rel=\"noopener\">Pubmed<\/a> <a href=\"https:\/\/journals.lww.com\/hemasphere\/Fulltext\/2021\/07000\/Extranucleolar_CYCLON_Staining_Pattern_Is_Strongly.3.aspx\" target=\"_blank\" rel=\"noopener\">DOI<\/a><\/span><\/li><li>Cappuccio G, et al. (2020) <em>De novo<\/em> SMARCA2 variants clustered outside the helicase domain cause a new recognizable syndrome with intellectual disability and blepharophimosis distinct from Nicolaides-Baraitser syndrome. <em>Genet Med.<\/em> 22(11):1838-1850. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32694869\/\" target=\"_blank\" rel=\"noopener\">Pubmed<\/a> <a href=\"https:\/\/doi.org\/10.1038\/s41436-020-0898-y\" target=\"_blank\" rel=\"noopener\">DOI<\/a><\/li><li>Crespo M, et al. (2020) Systematic genetic and proteomic screens during gametogenesis identify H2BK34 methylation as an evolutionary conserved meiotic mark. <em>Epigenetics Chromatin<\/em>. 13(1):35. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32933557\/\" target=\"_blank\" rel=\"noopener\">Pubmed<\/a> <a href=\"https:\/\/doi.org\/10.1186\/s13072-020-00349-5\" target=\"_blank\" rel=\"noopener\">DOI<\/a><\/li><li>Gressin R,\u00a0<em>et al.\u00a0<\/em> (2019) Lymphoma Study Association. A phase 2 study of rituximab, bendamustine, bortezomib and dexamethasone for first-line treatment of older patients with mantle cell lymphoma. <em>Haematologica<\/em>. 104(1):138-146. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30171024\/\" target=\"_blank\" rel=\"noopener\">Pubmed<\/a> <a href=\"https:\/\/doi.org\/10.3324\/haematol.2018.191429\" target=\"_blank\" rel=\"noopener\">DOI<\/a><\/li><li>Mietton F, <em>et al.<\/em> (2017<em>)<\/em> Selective BET inhibition as an antifungal therapeutic strategy.<em> Nat Commun <\/em>18;8:15482. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28516956\/\" target=\"_blank\" rel=\"noopener\">Pubmed<\/a> <a href=\"https:\/\/doi.org\/10.1038\/ncomms15482\" target=\"_blank\" rel=\"noopener\">DOI<\/a><\/li><li>Garc\u00eda-Oliver E, <em>et al. <\/em>(2017) Bdf1 Bromodomains are Essential for Meiosis and the Expression of Meiotic-Specific Genes. <em>PLoS Genet. <\/em>13(1):e1006541. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28068333\/\" target=\"_blank\" rel=\"noopener\">Pubmed<\/a> <a href=\"https:\/\/doi.org\/10.1371\/journal.pgen.1006541\" target=\"_blank\" rel=\"noopener\">DOI<\/a><\/li><li>El Kennani S, <em>et al.<\/em>\u00a0(2017) MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones <em>Epigenetics &amp; Chromatin<\/em> <strong>10<\/strong>:2. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28096900\/\" target=\"_blank\" rel=\"noopener\">Pubmed<\/a> <a href=\"https:\/\/doi.org\/10.1186\/s13072-016-0109-x\" target=\"_blank\" rel=\"noopener\">DOI<\/a><\/li><li>Emadali A, <em>et al. <\/em>(2016) Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms. <em>Blood<strong>.<\/strong><\/em> <strong>127<\/strong>(24):3040-53. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27060168\/\" target=\"_blank\" rel=\"noopener\">Pubmed<\/a> <a href=\"https:\/\/doi.org\/10.1182\/blood-2015-09-671040\" target=\"_blank\" rel=\"noopener\">DOI<\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30a2021 elementor-widget elementor-widget-text-editor\" data-id=\"30a2021\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-253 size-full\" src=\"https:\/\/translational-epigenetics.fr\/wp-content\/uploads\/2021\/02\/index-e1613994717238.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/strong><strong> \u00a0 ORCID profiles <\/strong>: <a href=\"https:\/\/orcid.org\/0000-0001-5511-6965\" target=\"_blank\" rel=\"noopener\">J. Govin<\/a>,<a href=\"https:\/\/orcid.org\/0000-0002-1976-2668\" target=\"_blank\" rel=\"noopener\"> A. Emadali<\/a>, <a href=\"https:\/\/orcid.org\/0000-0002-0796-7914\" target=\"_blank\" rel=\"noopener\">S. Carras.<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-db90a82 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"db90a82\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4f0dec1\" data-id=\"4f0dec1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8280899 elementor-widget elementor-widget-heading\" data-id=\"8280899\" data-element_type=\"widget\" id=\"contact\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Location &amp; contact<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c4a1b7 elementor-widget elementor-widget-text-editor\" data-id=\"5c4a1b7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>We are located in Grenoble, French Alps. Detailed directions are available <a href=\"https:\/\/iab.univ-grenoble-alpes.fr\/contact-iab-en?language=en\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-44a03a8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"44a03a8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-891d6bd\" data-id=\"891d6bd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68cc5a3 elementor-widget elementor-widget-google_maps\" data-id=\"68cc5a3\" data-element_type=\"widget\" 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-->\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Bienvenue !! We are a research team located in Grenoble, French Alpes, in the Department Signaling Through Chromatin of the Institute of Advanced Biosciences. We aim to explore chromatin signaling, how its deregulation can lead to pathological states and could be targeted to treat human diseases. We are always looking for talented members. Contact us! 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